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pentobarbital will minimize the level or impact of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Check Carefully (1)pentobarbital will lessen the extent or impact of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 indu